Limbic encephalitis due to antineuronal antibodies

Limbic Encephalitis due to Pancreatic Cancer.

tion (fig. 1A). Herpes simplex virus (HSV) type 1/2 as well as varicella zoster virus (VZV) polymerase chain reaction (PCR) of the CSF were both negative. Blood and CSF cultures were sterile; human immunodeficiency virus (HIV) and syphilis serology were negative. HuAbs could be detected by enzyme-linked immunosorbent assay and Western blot in serum and CSF (titers 1:1000 in serum and CSF; norma...

Limbic encephalitis: under-recognition of voltage-gated potassium channel antibodies.

lung cancer is associated with anti-Hu paraneoplastic LE. Since the report of Fukushima et al. [1] , we have shown the serum of their patient to be strongly positive for VGKC-Ab (2,354 p M ). The antibody titre decreased during treatment to 901 p M . This test is a radioimmunoassay utilising the binding of 125 I-radiolabelled -dendrotoxin to specific potassium channels. The results are expresse...

AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location.

OBJECTIVE To report the clinical and immunological features of a novel autoantigen related to limbic encephalitis (LE) and the effect of patients' antibodies on neuronal cultures. METHODS We conducted clinical analyses of 10 patients with LE. Immunoprecipitation and mass spectrometry were used to identify the antigens. Human embryonic kidney 293 cells expressing the antigens were used in immu...

Non-paraneoplastic limbic encephalitis associated with NMDAR and VGKC antibodies.

INTRODUCTION Limbic encephalitis (LE) is characterised by seizures and impairment of short-term memory as well as behavioural and psychiatric symptoms such as anxiety, depression, personality change and hallucinations. Onset of these symptoms is typically subacute over a few weeks or months but may also evolve over a few days. In many patients, limbic encephalitis is a paraneoplastic syndrome u...

Limbic encephalitis with mGluR5 antibodies and immunotherapy-responsive prosopagnosia.